Florida is the third most populous state in the United States and has the 16th highest rate of drug overdose (OD) deaths in the country. As of August 2019, 78 percent of the counties in Florida had at least one agency using ODMAP. As part of the grant, the Florida Department of Health developed an API to streamline EMS overdose data into an easy-to-use solution that interfaces with ODMAP, with the goal of identifying hot spots for response, treatment, and prevention follow-up activities. In parallel, Florida sought to engage law enforcement agencies statewide in ODMAP expansion efforts, in particular in capturing fatal OD data to be utilized for improvements in OD-related public safety outcomes. As the lead agency, the Seminole County Sheriff’s Office (SCSO) created an ODMAP and OD Data Center of Excellence, which includes public safety and health care (response, treatment, and prevention)-related best practices utilizing OD data.